…Either way Recent research carried out in humans, concludes that “Extensive epidemiologic studies have shown that the use of saccharin is not related to bladder cancer in humans”…
Structure - molecule produced by specific procedures of organic chemistry, The following empirical formula C7H5NO3S, 
and international designation of chemistry and biochemistry; 1,2- Benzisothiazol-3 (2H)-one 1,1-oxide, having a molecular weight of 183,18.
Service - as non-caloric sweetener (completely tolerated by diabetics), in food, dietary supplements, in toothpastes and pharmaceutical formulations for ingestion. Its sweetness is about 500 times that of sucrose (common sugar).
Use of safety -some controversy existed in years 70 of the last century on the possible mutagenic effects of saccharin. This controversy was due to some poorly conducted experimental studies and dubious conclusions, carried out in male rats, only those who have previously been exposed to the use of saccharin during pregnancy. The doses used in the animals were , a human equivalents to about 175 grams daily. The concentrations used by our production facility in the preparation of liquid formulations, varies between 30 and 40 to g 30 liters of the final product, This means that a package will be contained 200ml about 250 mg Saccharin. As the daily takes about 45ml (equal to 3 tablespoons), 20ml in ampoules, and 5ml (maximum) in drops, intake of sugar, nunca excederá os 65mg de sacarina[1]. Comparing intake with 175gr 65 mg can easily conclude that there are absolutely no grounds for concern about the use of saccharin in the products we produce.
Either way Recent research carried out in humans, concludes that “Extensive epidemiologic studies have shown that the use of saccharin is not related to bladder cancer in humans”[2], and “an independent analysis of many case studies - control, sponsored by the National Cancer Institute, involving 30101 patients from 10 geographic regions of the United States of America, concludes that there is no relationship between the use of saccharin and the incidence of bladder cancer”[3].
Sucrose is the sweetener because in effect (sweetener) noncaloric with more years of existence, and concomitantly also the most studied and subjected to mutagenic studies, teratogenic, toxicological, allergological, and epidemiological, currently being used daily by tens of millions of consumers in the world, highlighting the its complete safety and total security of use, at the recommended dosages, yet these far greater than we use in our products.
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[1] Repara-se que em 5ml ( máximo toma diária gotas), a dosagem de sacarina rondará os 7,2mg.
[2] Inclusana statement page. nº 416 the “Handbook of pharmaceutical excipients” Second Edition of American pharmaceutical press – London on 1994.
[3] “Handbook of food, drug, and cosmetic excipients” Page. nº340 CRC press Florida- USES in 1992. Outra bibliografia Arnold DL. “Two generation saccharin bioassays” environ health perspect 1983. Concil on scientific affairs. “Saccharin: Review of safety issues”. JAMA 1985
Author > Eduardo Ribeiro, CEO scientist Department | Quality control| Research and Development- Biogal, Biologia de Portugal Lda.
